Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730037 | 0.82 | RAB9A (0.80) | RAB9ANPC1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3851773 | 0.80 | ALDH1A1 (0.70) | RAB9ANPC1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL18420793 | 0.80 | SMN1; SMN2 (0.66) | RAB9ANPC1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3845645 | 0.77 | SORT1 (0.73) | RAB9ANPC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3846118 | 0.77 | SORT1 (0.73) | RAB9ANPC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL31511667 | 0.75 | NPC1 (0.59) | RAB9ANPC1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3851843 | 0.74 | NPC1 (0.57) | RAB9ANPC1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20332736 | 0.74 | SORT1 (0.71) | RAB9ANPC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4399143 | 0.73 | RAB9A (0.74) | RAB9ANPC1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL24670566 | 0.73 | NPC1 (0.65) | RAB9ANPC1ALDH1A1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |