Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183699 | 0.75 | AXL (0.50) | ALOX5APFEN1BRD4CREBBPUSP30 | |
| SCHEMBL3848418 | 0.73 | PDK2 (0.47) | ALOX5APFEN1MMP1MMP2MMP3 | |
| SCHEMBL29420340 | 0.72 | FFAR1 (0.44) | ALOX5APFEN1USP30FFAR1SCN9A | |
| SCHEMBL1953780 | 0.71 | MMP1 (0.43) | ALOX5APFEN1MMP1MMP2MMP3 | |
| SCHEMBL5549813 | 0.67 | MMP1 (0.49) | ALOX5APFEN1MMP1MMP2MMP3 | |
| SCHEMBL21612900 | 0.64 | RAB9A (0.39) | ALDH1A1NPC1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL21838886 | 0.64 | EGFR (0.51) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL21612951 | 0.64 | RAB9A (0.42) | ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL28541552 | 0.64 | NOS1 (0.37) | ALDH1A1L3MBTL1PLAUELANE | |
| SCHEMBL12985710 | 0.64 | ALDH1A1 (0.34) | ALDH1A1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641093-B | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP | 2013-05-29 | — | — | CN | disclosed |
| CN-101641093-A | Imidazotriazines and imidazopyrimidines as kinase inhibitors | INCYTE CORP US | 2010-02-03 | — | — | CN | disclosed |
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |