Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.41 |
| ▸ | PDE6D | O43924 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858272 | 0.92 | ESR1 (0.51) | ESR1GRIK2ESR2MLNRABCB11 | |
| SCHEMBL3853542 | 0.84 | GRIK2 (0.56) | ESR1GRIK2ALDH1A1TP53MAPT | |
| SCHEMBL12960217 | 0.83 | ESR1 (0.53) | ESR1GRIK2ESR2MLNRABCB11 | |
| SCHEMBL3854882 | 0.83 | PLA2G2A (0.49) | ESR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL635273 | 0.82 | ESR1 (0.52) | ESR1MAPTNPSR1ESR2MLNR | |
| Water SCHEMBL27846125 | 0.81 | ESR1 (0.50) | ESR1MAPTNPSR1ESR2MLNR | |
| SCHEMBL12960214 | 0.81 | ESR1 (0.50) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL3853126 | 0.81 | MAPT (0.48) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL3854951 | 0.81 | ESR1 (0.46) | ESR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3856500 | 0.80 | ESR1 (0.44) | ESR1PDE6DALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | ESR1 1756/4885PSEN1 2526/4885PSEN2 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.