Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.39 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857091 | 0.94 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL3851703 | 0.84 | PLA2G2A (0.39) | ESR1DYRK1AADAMTS5CYP19A1NPSR1 | |
| SCHEMBL3854484 | 0.84 | PLK4 (0.43) | DYRK1ANPSR1GAAMAPT | |
| SCHEMBL3854730 | 0.83 | ESR1 (0.39) | ESR1ADAMTS5CYP19A1NPSR1GAA | |
| SCHEMBL3853290 | 0.83 | ESR1 (0.40) | ESR1DYRK1AADAMTS5 | |
| SCHEMBL3851996 | 0.82 | GRIK2 (0.39) | ESR1GAAALDH1A1MAPTHPGD | |
| SCHEMBL3852585 | 0.80 | ESR1 (0.48) | ESR1NPSR1PDE6DALDH1A1TP53 | |
| SCHEMBL3850876 | 0.80 | PLA2G2A (0.51) | — | |
| SCHEMBL3853542 | 0.79 | GRIK2 (0.56) | ESR1NPSR1GAAALDH1A1TP53 | |
| SCHEMBL3854882 | 0.78 | PLA2G2A (0.49) | ESR1PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | claimed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | claimed |
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | ESR1 1756/4885DYRK1A 342/4885ADAMTS5 3847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.