Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313194 | 0.80 | TDP1 (0.47) | ELANEALDH1A1NSD2ATMTDP1 | |
| Diphenyl Ethanedioat SCHEMBL43364 | 0.79 | TDP1 (0.54) | ELANEALDH1A1NSD2ATMTDP1 | |
| SCHEMBL2721319 | 0.78 | CES2 (0.56) | ELANEALDH1A1PARP10NSD2ATM | |
| Diphenyl Ethanedioat SCHEMBL27328178 | 0.77 | TDP1 (0.52) | ELANEALDH1A1NSD2ATMTDP1 | |
| SCHEMBL27575859 | 0.77 | TDP1 (0.44) | ELANEALDH1A1NSD2ATMTDP1 | |
| SCHEMBL27541467 | 0.77 | TDP1 (0.44) | ELANEALDH1A1NSD2ATMTDP1 | |
| SCHEMBL4211366 | 0.77 | ELANE (0.49) | ELANEALDH1A1NSD2ATMTDP1 | |
| Benzophenone SCHEMBL16721022 | 0.76 | ELANE (0.67) | ELANEALDH1A1ATMTDP1L3MBTL1 | |
| SCHEMBL6555391 | 0.75 | TDP1 (0.42) | ELANEALDH1A1NSD2ATMTDP1 | |
| SCHEMBL39276 | 0.75 | TDP1 (0.57) | ELANEALDH1A1PARP10NSD2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | claimed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | claimed |
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | disclosed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | disclosed |
| EP-1730228-B1 | NANO-COMPOSITE AND METHOD THEREOF | BRIDGESTONE CORP (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-7579398-B2 | Nano-composite and compositions therefrom | BRIDGESTONE CORPORATION (JP) | 2009-08-25 | — | — | US | disclosed |
| US-7572855-B2 | Nano-composite and compositions manufactured thereof | BRIDGESTONE CORPORATION (JP) | 2009-08-11 | — | — | US | disclosed |
| US-20090182087-A1 | NANO-COMPOSITE AND COMPOSITIONS THEREFROM | BRIDGESTONE CORPORATION (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1730228-A1 | NANO-COMPOSITE AND METHOD THEREOF | Bridgestone Corporation (JP) | 2006-12-13 | — | — | EP | disclosed |
| US-20060173115-A1 | Nano-composite and compositions manufactured thereof | BRIDGESTONE CORPORATION (JP) | 2006-08-03 | — | — | US | disclosed |
| WO-2005095506-A1 | NANO-COMPOSITE AND METHOD THEREOF | BRIDGESTONE CORPORATION (JP) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | TPD52L2, TRDMT1, MCTS1 | ELANE 3819/4885ALDH1A1 2399/4885PARP10 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.