Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846015 | 0.86 | DRD2 (0.57) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3843977 | 0.86 | POLB (0.60) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3866800 | 0.85 | DRD2 (0.61) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3844108 | 0.84 | HTR2A (0.58) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3846851 | 0.83 | DRD2 (0.56) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3853473 | 0.82 | ALDH1A1 (0.56) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL4506148 | 0.82 | ALDH1A1 (0.53) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL4490509 | 0.81 | POLB (0.52) | DRD2HTR2AHTR7HTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL5267907 | 0.81 | ALDH1A1 (0.55) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL3849025 | 0.80 | GPR119 (0.56) | DRD2HTR2AHTR7HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038268-A2 | CARBONYLATED (AZA)CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007148208-A2 | CARBONYLATED (AZA) CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-27 | — | — | WO | disclosed |