Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 14/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857137 | 0.87 | PLA2G2A (0.61) | PLA2G2APLA2G1BMAPTALDH1A1TP53 | |
| SCHEMBL3853510 | 0.86 | PLA2G2A (0.48) | PLA2G2APLA2G1BMAPTALDH1A1TP53 | |
| SCHEMBL3854788 | 0.86 | PPARG (0.51) | PLA2G2AMAPTALDH1A1HPGDHTT | |
| SCHEMBL3855197 | 0.86 | GRIK2 (0.64) | PLA2G2APLA2G1BMAPTALDH1A1TP53 | |
| SCHEMBL3854601 | 0.85 | PLA2G2A (0.49) | PLA2G2APLA2G1BMAPTALDH1A1KMT2A | |
| SCHEMBL3853407 | 0.84 | PLA2G2A (0.49) | PLA2G2AMAPTALDH1A1HPGDPTPN1 | |
| SCHEMBL3853909 | 0.84 | SIRT2 (0.42) | PLA2G2APLA2G1BMAPTNPSR1 | |
| SCHEMBL3852304 | 0.84 | PLA2G2A (0.53) | PLA2G2APLA2G1BPTPN1 | |
| SCHEMBL9017573 | 0.80 | PLA2G2A (0.74) | PLA2G2APLA2G1BMAPTALDH1A1NPSR1 | |
| SCHEMBL3851703 | 0.79 | PLA2G2A (0.39) | PLA2G2AMAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | PLA2G2A 3821/4885PLA2G1B 3476/4885MAPT 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.