Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.41 |
| ▸ | ESR1 | P03372 | 7/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853281 | 0.88 | PLA2G2A (0.50) | PLA2G2APOLBMAPTNPSR1ADAM17 | |
| SCHEMBL3852236 | 0.86 | PSEN1 (0.46) | SIRT2PLA2G2AESR1POLBMAPT | |
| SCHEMBL3854587 | 0.86 | PPARG (0.48) | SIRT2SIRT1PSEN1PSEN2APH1B | |
| SCHEMBL3858272 | 0.86 | ESR1 (0.51) | ESR1 | |
| SCHEMBL3853483 | 0.84 | PLA2G2A (0.49) | PLA2G2AMAPTNPSR1PLA2G1B | |
| SCHEMBL3852304 | 0.83 | PLA2G2A (0.53) | SIRT2SIRT1PLA2G2APLA2G1BPSEN1 | |
| SCHEMBL3851703 | 0.81 | PLA2G2A (0.39) | SIRT2SIRT1PLA2G2AESR1POLB | |
| SCHEMBL3854601 | 0.80 | PLA2G2A (0.49) | SIRT2SIRT1PLA2G2AMAPTPLA2G1B | |
| SCHEMBL3852585 | 0.80 | ESR1 (0.48) | ESR1MAPTNPSR1PSEN1PSEN2 | |
| SCHEMBL3853407 | 0.80 | PLA2G2A (0.49) | PLA2G2AESR1MAPTPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | SIRT2 386/4885SIRT1 757/4885PLA2G2A 3821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.