Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581716 | 0.84 | LMNA (0.43) | MAPTLMNATP53P2RX3SMN1; SMN2 | |
| SCHEMBL3850211 | 0.77 | NPC1 (0.48) | MAPTLMNATP53P2RX3SMN1; SMN2 | |
| SCHEMBL3581997 | 0.74 | SMN1; SMN2 (0.48) | MAPTLMNAP2RX3SMN1; SMN2KMT2A | |
| SCHEMBL17493135 | 0.74 | BTK (0.41) | MAPTLMNAP2RX3SMN1; SMN2MEN1 | |
| SCHEMBL3586397 | 0.71 | P2RX3 (0.49) | MAPTLMNATP53P2RX3SMN1; SMN2 | |
| SCHEMBL3584979 | 0.71 | IDO1 (0.46) | LMNAMEN1KMT2ANPSR1NPC1 | |
| SCHEMBL3581597 | 0.71 | MAPT (0.46) | MAPTLMNATP53P2RX3SMN1; SMN2 | |
| SCHEMBL3576887 | 0.71 | RAB9A (0.43) | MAPTLMNAP2RX3SMN1; SMN2MEN1 | |
| SCHEMBL3855261 | 0.70 | NPC1 (0.52) | MAPTLMNATP53P2RX3SMN1; SMN2 | |
| SCHEMBL3584780 | 0.69 | NPBWR1 (0.46) | LMNAP2RX3SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104670-A2 | NOVEL TRIAZINEDIONE DERIVATIVES AS GABA-B RECEPTOR MODULATORS | Addex Pharma SA (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008056257-A2 | NOVEL TRIAZINEDIONE DERIVATIVES AS GABA-B RECEPTOR MODULATORS | ADDEX PHARMA S.A (CH) | 2008-05-15 | — | — | WO | disclosed |