Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850395 | 0.88 | TGFBR1 (0.38) | SMN1; SMN2MEN1KMT2ATGFBR1FYN | |
| SCHEMBL3849706 | 0.85 | FLT3 (0.46) | SMN1; SMN2CLK1DYRK1AFYNFLT3 | |
| SCHEMBL3852515 | 0.84 | L3MBTL1 (0.40) | TGFBR1CLK1DYRK1AFYNRAD52 | |
| SCHEMBL3849015 | 0.84 | FAAH (0.39) | TGFBR1TGFBR2 | |
| SCHEMBL3846108 | 0.83 | FLT3 (0.41) | TGFBR1FYNFLT3AKT1AKT2 | |
| SCHEMBL3845550 | 0.83 | FLT3 (0.41) | MEN1KMT2ATGFBR1FYNFLT3 | |
| SCHEMBL3847038 | 0.83 | FLT3 (0.38) | TGFBR1CLK1DYRK1AFYNFLT3 | |
| SCHEMBL3846734 | 0.82 | MKNK1 (0.44) | TGFBR1FYNFLT3AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL3845911 | 0.82 | GABRA1 (0.41) | GABRA1GABRB2SMN1; SMN2MAPTMEN1 | |
| SCHEMBL3848374 | 0.82 | FYN (0.45) | TGFBR1FYNFLT3TGFBR2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |