Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NRAS | P01111 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5853314 | 0.99 | FLT3 (0.41) | FLT3ROCK2ROCK1NRASNPC1 | |
| Hydrochloric Acid SCHEMBL3849246 | 0.87 | FLT3 (0.39) | FLT3ROCK2ROCK1NRASNPC1 | |
| Hydrochloric Acid SCHEMBL3846959 | 0.85 | ALDH1A1 (0.45) | FLT3ROCK2ROCK1NRASPTK6 | |
| Hydrochloric Acid SCHEMBL3850519 | 0.85 | GSK3B (0.42) | FLT3ROCK2ROCK1NRASNPC1 | |
| Hydrochloric Acid SCHEMBL3854256 | 0.84 | ALDH1A1 (0.46) | FLT3NRASNPC1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL3845647 | 0.83 | LRRK2 (0.45) | FLT3ROCK2ROCK1NRASNPC1 | |
| Hydrochloric Acid SCHEMBL3845019 | 0.83 | FLT3 (0.43) | FLT3ROCK2NRASPTK6AURKB | |
| SCHEMBL4712318 | 0.82 | KDM4E (0.41) | FLT3ROCK2ROCK1NRASCHEK1 | |
| SCHEMBL3848486 | 0.82 | MAPT (0.46) | ROCK2NPC1RAB9AMAPTPOLB | |
| SCHEMBL4715804 | 0.82 | LOXL2 (0.43) | FLT3ROCK2ROCK1NRASNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |