Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848405 | 0.79 | KDM4E (0.36) | HPGDKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL3855952 | 0.79 | HDAC1 (0.35) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3854778 | 0.77 | NPC1 (0.33) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3850285 | 0.77 | ALDH1A1 (0.49) | HPGDKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL3846579 | 0.76 | SLC6A3 (0.52) | KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL5903687 | 0.73 | HDAC1 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL27633896 | 0.73 | HDAC1 (0.56) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3850430 | 0.73 | FAAH (0.34) | HPGDKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL5903871 | 0.72 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903863 | 0.72 | HDAC1 (0.65) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |