Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 4/20 | 0.31 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850431 | 0.83 | — | — | |
| SCHEMBL3847898 | 0.82 | ALDH1A1 (0.40) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL3847269 | 0.81 | ALDH1A1 (0.40) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL3848554 | 0.81 | LIPE (0.37) | KDM4EALDH1A1HSD17B10LIPEMAPT | |
| SCHEMBL3848405 | 0.80 | KDM4E (0.36) | FAAHKDM4EALDH1A1POLBHPGD | |
| SCHEMBL3849289 | 0.79 | SLC6A3 (0.41) | ALDH1A1MAPT | |
| SCHEMBL3851999 | 0.76 | — | — | |
| SCHEMBL3850713 | 0.74 | F2RL3 (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3855945 | 0.73 | HDAC1 (0.43) | FAAHKDM4EALDH1A1POLBHPGD | |
| SCHEMBL19730343 | 0.72 | UCHL1 (0.42) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |