Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20220774 | 0.90 | REN (0.49) | RENTP53LMNAMAPTPOLB | |
| SCHEMBL1421010 | 0.86 | REN (0.48) | RENTP53LMNAMAPTPOLB | |
| SCHEMBL13348007 | 0.80 | LMNA (0.40) | RENTP53LMNAMAPTPOLB | |
| SCHEMBL12514949 | 0.79 | TP53 (0.40) | RENTP53LMNAMAPTPOLB | |
| SCHEMBL4089055 | 0.74 | MAPK1 (0.39) | RENTP53LMNAMAPTPOLB | |
| SCHEMBL24079283 | 0.68 | MAPK1 (0.40) | TP53LMNAMAPTPOLBNPC1 | |
| SCHEMBL19909627 | 0.68 | MAPK1 (0.43) | MAPTPOLBKDM4ENPC1RAB9A | |
| SCHEMBL28470543 | 0.68 | MAPK1 (0.40) | TP53MAPTPOLBKDM4ENPC1 | |
| SCHEMBL28626993 | 0.68 | MAPK1 (0.40) | TP53MAPTPOLBKDM4ENPC1 | |
| SCHEMBL21357724 | 0.67 | MAPK1 (0.38) | TP53LMNAMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009154300-A2 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-23 | — | — | WO | disclosed |