Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.79 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | STAT3 | P40763 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | APP | P05067 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.60 |
| ▸ | BACE1 | P56817 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857596 | 1.00 | TOP2A (0.79) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| Ethyl Curcumin SCHEMBL8965258 | 0.89 | TOP2A (1.00) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| Ethyl Curcumin SCHEMBL8965263 | 0.89 | TOP2A (1.00) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| SCHEMBL3842259 | 0.88 | ALOX5 (0.81) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| SCHEMBL3855984 | 0.88 | ALOX5 (0.81) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| SCHEMBL25192200 | 0.85 | MAPT (0.75) | TOP2AMAPTTRPA1MAOAMAOB | |
| SCHEMBL31233159 | 0.85 | MAPT (0.75) | TOP2AMAPTTRPA1MAOAMAOB | |
| SCHEMBL1374497 | 0.84 | TOP2A (0.89) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| SCHEMBL27686673 | 0.84 | TOP2A (0.89) | TOP2AALOX5NFKB1STAT3NFKB2 | |
| SCHEMBL29929626 | 0.84 | TOP2A (0.89) | TOP2AALOX5NFKB1STAT3NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589123-B2 | Chemical compounds | PHYTOPHARM PLC (GB) | 2009-09-15 | — | — | US | disclosed |
| CN-101511350-A | Dioxo-alkanes and dioxo-alkenes | PHYTOPHARM PLC (GB) | 2009-08-19 | — | — | CN | disclosed |
| US-20080045591-A1 | Chemical Compounds | VECTURA LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045591-A1 | Chemical Compounds | CYP11B1, CYP11B2, CYP2S1 | TOP2A 1425/4885ALOX5 1556/4885NFKB1 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.