Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 5/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.62 |
| ▸ | DNPH1 | O43598 | 3/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.62 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 1/20 | 0.62 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.62 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.62 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.62 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862068 | 0.96 | P2RX3 (0.61) | P2RY1P2RY2DNPH1ADORA1SRC | |
| SCHEMBL1905822 | 0.89 | P2RX3 (0.72) | P2RY1P2RY2DNPH1ADORA1SRC | |
| SCHEMBL1905818 | 0.89 | P2RX3 (0.72) | P2RY1P2RY2DNPH1ADORA1SRC | |
| SCHEMBL3859612 | 0.89 | P2RY1 (0.67) | P2RY1P2RY2DNPH1ADORA1SRC | |
| Thioinosine Monophosphate SCHEMBL379366 | 0.89 | DNPH1 (0.77) | P2RY1P2RY2DNPH1ADORA1SRC | |
| Thioinosine Monophosphate SCHEMBL15810629 | 0.89 | DNPH1 (0.77) | P2RY1P2RY2DNPH1ADORA1SRC | |
| Thioinosine Monophosphate SCHEMBL379365 | 0.89 | DNPH1 (0.77) | P2RY1P2RY2DNPH1ADORA1SRC | |
| Thioinosine Monophosphate SCHEMBL29746215 | 0.89 | DNPH1 (0.77) | P2RY1P2RY2DNPH1ADORA1SRC | |
| SCHEMBL1906288 | 0.88 | P2RY1 (0.74) | P2RY1P2RY2DNPH1ADORA1SRC | |
| SCHEMBL1906291 | 0.88 | P2RY1 (0.74) | P2RY1P2RY2DNPH1ADORA1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1825254-A4 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | PROMETHEUS LAB INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1825254-A2 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | Prometheus Laboratories, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060216726-A1 | Method for optimizing thiopurine efficacy and toxicity using mass spectrometry | PROMETHEUS LABORATORIES INC. (US) | 2006-09-28 | — | — | US | disclosed |
| WO-2006055527-A2 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | PROMETHEUS LABORATORIES INC. (US) | 2006-05-26 | — | — | WO | disclosed |