Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPRG | P23470 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865719 | 0.92 | HTR2C (0.42) | ASIC3HRH3CYP2D6HTR2CHTR2B | |
| SCHEMBL3868238 | 0.91 | HTR2C (0.46) | ASIC3HRH3CYP2D6HTR2CHTR2B | |
| SCHEMBL3869907 | 0.88 | FFAR1 (0.37) | HRH3CYP2D6FFAR1EGFR | |
| SCHEMBL3864024 | 0.83 | TAAR1 (0.36) | HRH3CYP2D6FFAR1 | |
| SCHEMBL236614 | 0.79 | ASIC3 (0.45) | ASIC3HRH3CYP2D6HTR2CHTR2B | |
| SCHEMBL12488285 | 0.77 | MMP12 (0.46) | HRH3HTR2BFFAR1 | |
| SCHEMBL3859047 | 0.73 | MAP3K14 (0.39) | L3MBTL1 | |
| SCHEMBL232937 | 0.72 | HTR2C (0.47) | ASIC3HRH3HTR2CHTR2BFFAR1 | |
| SCHEMBL2151068 | 0.72 | CYP2D6 (0.32) | HRH3CYP2D6FFAR1 | |
| SCHEMBL3860771 | 0.72 | HTT (0.39) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | claimed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | claimed |
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |