Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3868238 | 0.96 | HTR2C (0.46) | HTR2CHTR2BASIC3EGFRHRH3 | |
| SCHEMBL3858481 | 0.92 | ASIC3 (0.43) | HTR2CHTR2BASIC3EGFRHRH3 | |
| SCHEMBL3869907 | 0.86 | FFAR1 (0.37) | EGFRHRH3CYP2D6ALDH1A1FFAR1 | |
| SCHEMBL232937 | 0.82 | HTR2C (0.47) | HTR2CHTR2BASIC3EGFRHRH3 | |
| SCHEMBL3864024 | 0.81 | TAAR1 (0.36) | HRH3CYP2D6FFAR1 | |
| SCHEMBL235456 | 0.78 | HTR2C (0.52) | HTR2CHTR2BASIC3HRH3CHRNB4 | |
| SCHEMBL2180350 | 0.77 | HTR2C (0.51) | HTR2CHTR2BASIC3EGFRHRH3 | |
| SCHEMBL4178362 | 0.75 | LMNA (0.47) | HTR2CHTR2BASIC3EGFRHRH3 | |
| SCHEMBL12488285 | 0.75 | MMP12 (0.46) | HTR2BHRH3FFAR1 | |
| SCHEMBL236614 | 0.74 | ASIC3 (0.45) | HTR2CHTR2BASIC3HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |