Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20844825 | 1.00 | CFD (0.39) | CFDTPSB2TACR1ANPEPENPEP | |
| SCHEMBL7241495 | 0.85 | TACR1 (0.40) | CFDTPSB2TACR1ANPEPENPEP | |
| SCHEMBL20844633 | 0.85 | TACR1 (0.40) | CFDTPSB2TACR1ANPEPENPEP | |
| SCHEMBL25269085 | 0.79 | PNMT (0.47) | CFDTPSB2IDO1 | |
| SCHEMBL382070 | 0.79 | PNMT (0.47) | CFDTPSB2IDO1 | |
| SCHEMBL30839508 | 0.79 | ADRB1 (0.50) | CFDTPSB2ANPEPENPEPRAB9A | |
| SCHEMBL24527613 | 0.79 | AOC3 (0.42) | CFDTPSB2TACR1ANPEPENPEP | |
| SCHEMBL3807032 | 0.79 | CPN1 (0.45) | CFDTPSB2ANPEPENPEPCYP2D6 | |
| SCHEMBL27199248 | 0.79 | ADRB1 (0.50) | CFDTPSB2ANPEPENPEPRAB9A | |
| SCHEMBL11664457 | 0.79 | TACR1 (0.41) | TACR1ANPEPENPEPCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |