Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3957460 | 0.91 | MTNR1A (0.41) | ALOX5EPHX2PTGESSMN1; SMN2ALDH1A1 | |
| SCHEMBL233409 | 0.89 | ALOX5 (0.33) | ALOX5EPHX2MTNR1AMTNR1BCNR1 | |
| SCHEMBL10237439 | 0.89 | ALOX5 (0.33) | ALOX5EPHX2MTNR1AMTNR1BCNR1 | |
| SCHEMBL233636 | 0.89 | ALOX5 (0.33) | ALOX5EPHX2MTNR1AMTNR1BCNR1 | |
| SCHEMBL15461598 | 0.85 | RIPK1 (0.36) | ALOX5SMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL232521 | 0.84 | PNMT (0.33) | LMNARIPK1 | |
| SCHEMBL232520 | 0.84 | PNMT (0.33) | LMNARIPK1 | |
| SCHEMBL235439 | 0.84 | PNMT (0.33) | LMNARIPK1 | |
| SCHEMBL3839542 | 0.81 | PTPN11 (0.41) | ALOX5EPHX2PTGESMTNR1AMTNR1B | |
| SCHEMBL236990 | 0.80 | CNR1 (0.35) | ALOX5EPHX2MTNR1AMTNR1BCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |