Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.70 |
| ▸ | MEN1 | O00255 | 13/20 | 0.70 |
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12280667 | 0.92 | KMT2A (0.66) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL12281794 | 0.88 | KMT2A (0.73) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL3862150 | 0.84 | GLA (0.67) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL12280671 | 0.83 | KMT2A (0.64) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL15078624 | 0.82 | KMT2A (0.65) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL3861928 | 0.80 | MEN1 (0.47) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL27952547 | 0.79 | KMT2A (0.58) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL28471029 | 0.78 | KMT2A (0.66) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL4710987 | 0.78 | JUN (0.59) | KMT2AMEN1NPC1LMNAHPGD | |
| SCHEMBL4710988 | 0.78 | JUN (0.59) | KMT2AMEN1NPC1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975597-B1 | QUINOLINE DERIVATIVES, HAVING IN PARTICULAR ANTIVIRAL PROPERTIES, PREPARATION AND BIOLOGICAL APPLICATIONS THEREOF | CENTRE NAT RECH SCIENT (FR) | 2009-09-02 | — | — | EP | disclosed |
| US-6670377-B1 | Inhibitory properties of human immunodeficiency virus integrase | CENTRE NATIONAL DE LA RECHERCHE (FR) | 2003-12-30 | — | — | US | disclosed |