Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL10011961 | 1.00 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7998952 | 1.00 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL366070 | 1.00 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7998953 | 1.00 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL6520765 | 0.98 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL5327761 | 0.98 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7459478 | 0.93 | ALOX15 (0.45) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL150535 | 0.92 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL4347082 | 0.92 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL20489207 | 0.92 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113310960-B | Sulfur quantum dot synthesis method and sulfur quantum dot-based Fe determination method2+And H2O2Method (2) | 四川中科微纳科技有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-113310960-A | Sulfur quantum dot synthesis method and sulfur quantum dot-based Fe determination method+2And H2O2Method (2) | 四川中科微纳科技有限公司 | 2021-08-27 | — | — | CN | claimed |
| CN-104271595-A | Proteins toxic to hemipteran insect species | MONSANTO TECHNOLOGY LLC | 2015-01-07 | — | — | CN | claimed |
| US-20130116192-A1 | N-(AMINOACYL)-AMINO COMPOUND | WETH GOSBERT (DE) | 2013-05-09 | — | — | US | claimed |
| EP-2358894-A1 | TEST FOR PREDICTING NEUTRALIZATION OF ASPARAGINASE ACTIVITY | Erytech Pharma (FR) | 2011-08-24 | — | — | EP | claimed |
| WO-2010052315-A1 | TEST FOR PREDICTING NEUTRALIZATION OF ASPARAGINASE ACTIVITY | ERYTECH PHARMA (FR) | 2010-05-14 | — | — | WO | claimed |
| CN-1600852-A | Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup B | AMERICAN CYANAMID CO (US) | 2005-03-30 | — | — | CN | claimed |
| CN-1294628-A | Mutations causing attenuation of measles virus or human respiratory syncytial virus subgroup B | AMERICAN CYANAMID CO (US) | 2001-05-09 | — | — | CN | claimed |
| CN-1273603-A | Attenuated respiratory syncytial virus | AMERICAN CYANAMID CO (US) | 2000-11-15 | — | — | CN | claimed |
| US-6048728-A | PROPAGATING CELLS; CONTACTING CELLS WITH A CULTURE MEDIUM, WHEREIN SAID COMPONENTS ARE SUFFICIENT TO INCREASE THE CULTURES PRODUCTIVE SHELF LIFE BY MAINTAINING CELLS IN A PROPAGATION STATE | CHIRON CORPORATION (US) | 2000-04-11 | — | — | US | claimed |
| CN-1232504-A | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of order designated mononegavirales | AMERICAN CYANAMID CO (US) | 1999-10-20 | — | — | CN | claimed |
| EP-0332225-B1 | ANTIBODY TO POLYPEPTIDES COMPLEMENTARY TO PEPTIDES OR PROTEINS HAVING AN AMINO ACID SEQUENCE OR NUCLEOTIDE CODING SEQUENCE AT LEAST PARTIALLY KNOWN AND METHODS OF DESIGN THEREFOR | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-04-21 | — | — | EP | claimed |
| US-20240181023-A1 | FUNCTIONALIZED BIOCATALYTICAL COMPOSITIONS | PERSEO PHARMA AG (CH) | 2024-06-06 | — | — | US | disclosed |
| US-20240150752-A1 | METHODS AND COMPOSITIONS FOR MUTAGENESIS SCREENING IN MAMMALIAN CELLS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-09 | — | — | US | disclosed |
| US-20240141330-A1 | METHODS AND COMPOSITIONS FOR MUTAGENESIS SCREENING IN MAMMALIAN CELLS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-02 | — | — | US | disclosed |
| CN-117813378-A | Compositions and methods for in vivo protease profiling by immunocyte display | 乔治亚技术研究公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-0269220-A2 | Derivatives of alpha-hANP and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-06-01 | — | — | EP | disclosed |
| CN-86106522-A | Expression and Secretion of Heterologous Proteins Using Yarrowia lipolytica Transformants | — | 1987-09-16 | — | — | CN | disclosed |
| CN-86102644-A | Expression of factor VII and IX Activity in mammalian cells | — | 1987-06-03 | — | — | CN | disclosed |
| WO-1985001746-A1 | THE MANUFACTURE AND EXPRESSION OF GENES FOR THAUMATIN | BEATRICE COMPANIES, INC. (US) | 1985-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116192-A1 | N-(AMINOACYL)-AMINO COMPOUND | ASS1, AADAT, ARGLU1 | ALOX15 4356/4885BLM 3567/4885PMP22 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.