Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742468 | 0.91 | ALDH1A1 (0.42) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL31459654 | 0.86 | HDAC4 (0.43) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL5642482 | 0.86 | HDAC4 (0.43) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL31459378 | 0.86 | HDAC4 (0.43) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL28677184 | 0.86 | ALDH1A1 (0.41) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL25280986 | 0.86 | HTR2C (0.40) | ALDH1A1NPC1LMNATP53NFKB1 | |
| Hydrochloric Acid SCHEMBL25274762 | 0.85 | HTR2C (0.39) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL1769351 | 0.80 | HDAC4 (0.41) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL30929543 | 0.80 | HDAC4 (0.41) | ALDH1A1NPC1LMNATP53NFKB1 | |
| SCHEMBL3868254 | 0.79 | HDAC4 (0.42) | ALDH1A1NPC1LMNATP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861072-A | Preparation method of aryl cyclopropane compound | 上海麦克林生化科技有限公司 | 2021-12-31 | — | — | CN | disclosed |
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1877377-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | Wyeth (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006118955-A2 | PROCESS FOR PREPARING 3,3-DISUBSTITUTED OXINDOLES AND THIO-OXINDOLES | WYETH (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20060247441-A1 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
| EP-0459285-B1 | Ortho-substituted benzyl esters of cyclopropane carboxylic acids | BASF AG (DE) | 1994-12-14 | — | — | EP | disclosed |
| US-5371268-A | Ortho-substituted benzyl esters of cyclopropanecarboxylic acids | BASF AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | disclosed |
| EP-0459285-A1 | Ortho-substituted benzyl esters of cyclopropane carboxylic acids | BASF Aktiengesellschaft (DE) | 1991-12-04 | — | — | EP | disclosed |
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319204-A1 | PROCESS FOR THE SYNTHESIS OF PROGESTERONE RECEPTOR MODULATORS | OXTR, PGR, NR3C2 | ALDH1A1 2689/4885NPC1 2237/4885LMNA 3507/4885 |
| US-20060247441-A1 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | TPMT, TH, HTR3C | ALDH1A1 1493/4885NPC1 4132/4885LMNA 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.