Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 18/20 | 0.51 |
| ▸ | KDM6B | O15054 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KDM4A | O75164 | 3/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718472 | 0.77 | KDM4C (0.66) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL17723987 | 0.76 | KDM4C (0.71) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL18421265 | 0.74 | KDM4C (0.51) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL4302547 | 0.72 | AOC1 (0.53) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL29892972 | 0.72 | KDM4C (0.52) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL5617078 | 0.71 | TDP1 (0.53) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL17711000 | 0.71 | KDM4C (0.51) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL17560234 | 0.70 | PTGS1 (0.42) | KDM4CTDP1SIRT3 | |
| SCHEMBL18422044 | 0.70 | IRAK4 (0.50) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL29601833 | 0.70 | IRAK4 (0.50) | KDM4CKDM6BKDM4EKDM4AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585885-B2 | Pyrrolidine derivatives useful as BACE inhibitors | ELI LILLY AND COMPANY (US) | 2009-09-08 | — | — | US | disclosed |
| US-20070213331-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BASE INHIBITORS | ELI LILLY AND COMPANY | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213331-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BASE INHIBITORS | BACE1, BACE2, PSEN1 | KDM4C 2623/4885KDM6B 1726/4885KDM4E 1975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.