Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.54 |
| ▸ | DRD3 | P35462 | 12/20 | 0.54 |
| ▸ | DRD4 | P21917 | 5/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294007 | 0.74 | DRD2 (0.67) | DRD2DRD3DRD4OPRM1HTR2A | |
| SCHEMBL5023619 | 0.73 | DRD2 (0.51) | DRD2DRD3DRD4OPRM1HTR2A | |
| SCHEMBL27237946 | 0.73 | DRD2 (0.60) | DRD2DRD3DRD4HTR2AOPRK1 | |
| SCHEMBL5027734 | 0.73 | USP2 (0.50) | — | |
| Acetic Acid SCHEMBL28309082 | 0.72 | DRD2 (0.79) | DRD2DRD3DRD4OPRM1HTR2A | |
| SCHEMBL5026280 | 0.71 | HRH3 (0.44) | — | |
| SCHEMBL14188952 | 0.70 | DRD2 (0.57) | DRD2DRD3DRD4OPRM1HTR2A | |
| SCHEMBL3871229 | 0.70 | MAPT (0.47) | DRD2DRD3DRD4HTR2AADRB1 | |
| SCHEMBL3864015 | 0.70 | MEN1 (0.41) | — | |
| SCHEMBL246696 | 0.69 | DRD2 (0.56) | DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670775-A4 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-04-22 | — | — | EP | claimed |
| JP-2007504174-A | — | — | 2007-03-01 | — | — | JP | claimed |
| EP-1670775-A1 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-06-21 | — | — | EP | claimed |
| WO-2005021523-A1 | PIPERAZINE SUBSTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED TECHNOLOGIES, INC. (CA) | 2005-03-10 | — | — | WO | claimed |