Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026265 | 0.85 | KMT2A (0.59) | KCNH2CHRM1ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL4185164 | 0.78 | KCNH2 (0.57) | HRH3KCNH2CHRM1ALDH1A1KMT2A | |
| SCHEMBL3860853 | 0.76 | OPRM1 (0.51) | KCNH2CHRM1ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL5027734 | 0.75 | USP2 (0.50) | ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL3862213 | 0.74 | KMT2A (0.52) | KCNH2KMT2A | |
| SCHEMBL5023966 | 0.73 | KCNH2 (0.49) | KCNH2CHRM1ALDH1A1 | |
| SCHEMBL18390261 | 0.72 | MEN1 (0.54) | HRH3KCNH2CHRM1KMT2A | |
| SCHEMBL3864015 | 0.72 | MEN1 (0.41) | KMT2A | |
| SCHEMBL3957121 | 0.72 | MEN1 (0.52) | ALDH1A1KMT2A | |
| SCHEMBL3871229 | 0.72 | MAPT (0.47) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |