Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.51 |
| ▸ | DRD3 | P35462 | 17/20 | 0.51 |
| ▸ | DRD4 | P21917 | 10/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861148 | 0.73 | DRD2 (0.54) | DRD2DRD3DRD4OPRM1OPRK1 | |
| SCHEMBL13801241 | 0.73 | DRD2 (0.62) | DRD2DRD3DRD4OPRK1HTR2A | |
| SCHEMBL1194044 | 0.73 | DRD2 (0.61) | DRD2DRD3DRD4OPRK1DRD5 | |
| SCHEMBL1193606 | 0.70 | DRD2 (0.67) | DRD2DRD3DRD4OPRM1OPRK1 | |
| SCHEMBL10294007 | 0.70 | DRD2 (0.67) | DRD2DRD3DRD4OPRM1HTR2A | |
| SCHEMBL1193746 | 0.69 | DRD2 (0.72) | DRD2DRD3DRD4HTR2A | |
| SCHEMBL5023769 | 0.68 | KDM4E (0.43) | — | |
| SCHEMBL5024049 | 0.68 | ALDH1A1 (0.45) | — | |
| SCHEMBL29282473 | 0.68 | DRD2 (0.67) | DRD2DRD3DRD4OPRK1ADRB1 | |
| SCHEMBL3799756 | 0.68 | OPRK1 (0.58) | DRD2DRD3DRD4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |