Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ME2 | P23368 | 1/20 | 0.43 |
| ▸ | ME1 | P48163 | 1/20 | 0.43 |
| ▸ | ME3 | Q16798 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864015 | 0.85 | MEN1 (0.41) | CYP2C9HPGDCYP2C19MAPK1MEN1 | |
| SCHEMBL3871229 | 0.82 | MAPT (0.47) | ALDH1A1HPGDMEN1KMT2AME2 | |
| SCHEMBL12273079 | 0.75 | CTSL (0.46) | USP2ALDH1A1CYP1A2HSD17B10CYP2C9 | |
| SCHEMBL5026280 | 0.75 | HRH3 (0.44) | ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL3861148 | 0.73 | DRD2 (0.54) | — | |
| SCHEMBL5026265 | 0.72 | KMT2A (0.59) | ALDH1A1CYP2C9HPGDMEN1KMT2A | |
| Fluoride SCHEMBL27569822 | 0.72 | MEN1 (0.56) | USP2ALDH1A1CYP1A2HSD17B10CYP2C9 | |
| SCHEMBL5239356 | 0.72 | MEN1 (0.68) | USP2ALDH1A1CYP1A2HSD17B10CYP2C9 | |
| SCHEMBL3862213 | 0.70 | KMT2A (0.52) | MEN1KMT2APOLBGAA | |
| SCHEMBL5017426 | 0.70 | RAB9A (0.60) | ALDH1A1CYP1A2HSD17B10CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |