Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 12/20 | 0.38 |
| ▸ | CA1 | P00915 | 12/20 | 0.38 |
| ▸ | CA2 | P00918 | 12/20 | 0.38 |
| ▸ | CA6 | P23280 | 12/20 | 0.38 |
| ▸ | CA7 | P43166 | 12/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL936396 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL198231 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL26257 | 0.83 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL1276519 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL9517821 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7102453 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL6546528 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL2376967 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL10885400 | 0.80 | KMT2A (0.46) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL10882871 | 0.80 | KMT2A (0.46) | ALDH1A1KDM4EMEN1NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3940067-A1 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | Synlogic Operating Company, Inc. (US) | 2022-01-19 | — | — | EP | claimed |
| CN-107208044-B | Bacteria engineered to treat diseases associated with hyperammonemia | 同生运营公司 | 2021-08-13 | — | — | CN | claimed |
| EP-3227440-B1 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC OPERATING CO INC (US) | 2021-07-14 | — | — | EP | claimed |
| EP-3307879-A2 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | Synlogic, Inc. (US) | 2018-04-18 | — | — | EP | claimed |
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | claimed |
| EP-3227440-A1 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | Synlogic, Inc. (US) | 2017-10-11 | — | — | EP | claimed |
| WO-2017139697-A1 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-08-17 | — | — | WO | claimed |
| WO-2016200614-A2 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2016-12-15 | — | — | WO | claimed |
| US-9487764-B2 | Bacteria engineered to treat diseases associated with hyperammonemia | SYNLOGIC, INC. (US) | 2016-11-08 | — | — | US | claimed |
| US-20160177274-A1 | Bacteria Engineered to Treat Diseases Associated with Hyperammonemia | SYNLOGIC, INC. | 2016-06-23 | — | — | US | claimed |
| WO-2016090343-A1 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2016-06-09 | — | — | WO | claimed |
| CN-101597589-B | Method for producing l-amino acid using bacteria belonging to the genus escherichia | AJINOMOTO KK | 2011-08-24 | — | — | CN | claimed |
| CN-101597589-A | Produce the amino acid whose method of L-by the Escherichia bacterium | AJINOMOTO KK (JP) | 2009-12-09 | — | — | CN | claimed |
| US-7618804-B2 | Method for producing L-amino acid using bacteria belonging to the genus Escherichia | AJINOMOTO CO., INC. (JP) | 2009-11-17 | — | — | US | claimed |
| US-20080261278-A1 | METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA BELONGING TO THE GENUS ESCHERICHIA | TABOLINA EKATERINA ALEKSANDROV | 2008-10-23 | — | — | US | claimed |
| EP-1526181-B1 | Method for producing l-amino acid using bacteria belonging to the genus escherichia | AJINOMOTO KK (JP) | 2007-05-02 | — | — | EP | claimed |
| US-20050239175-A1 | Method for producing L-amino acid using bacteria belonging to the genus Escherichia | AJINOMOTO CO., INC. (JP) | 2005-10-27 | — | — | US | claimed |
| EP-1526181-A1 | Method for producing l-amino acid using bacteria belonging to the genus escherichia | Ajinomoto Co., Inc. (JP) | 2005-04-27 | — | — | EP | claimed |
| CN-1373226-A | Method for producing L-amino acid by bacterium belonging to genus Escherichia | AJINOMOTO KK (JP) | 2002-10-09 | — | — | CN | claimed |
| EP-1239041-A2 | Method for producing L-amino acid using bacteria belonging to the genus Escherichia | Ajinomoto Co., Inc. (JP) | 2002-09-11 | — | — | EP | claimed |