Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862213 | 0.80 | KMT2A (0.52) | POLBMEN1KMT2ASIGMAR1 | |
| SCHEMBL5023966 | 0.79 | KCNH2 (0.49) | LMNAALDH1A1PKM | |
| SCHEMBL12311337 | 0.78 | KDM1A (0.54) | HTR7LMNANPSR1POLBMEN1 | |
| SCHEMBL3860844 | 0.77 | CHRM4 (0.43) | HTR7LMNAALDH1A1 | |
| SCHEMBL7737516 | 0.77 | HTR7 (0.58) | HTR7ALDH1A1NPSR1POLBMEN1 | |
| SCHEMBL3869725 | 0.73 | KDM4E (0.40) | ALDH1A1MEN1KMT2ASIGMAR1SMN1; SMN2 | |
| SCHEMBL12311274 | 0.72 | ACKR3 (0.56) | ALDH1A1NPSR1PKMSIGMAR1HTT | |
| SCHEMBL5024637 | 0.72 | KDM1A (0.47) | HTR7LMNAALDH1A1KMT2AHTT | |
| SCHEMBL5026280 | 0.71 | HRH3 (0.44) | ALDH1A1KMT2A | |
| SCHEMBL4932045 | 0.70 | DPP7 (0.58) | HTR7LMNAALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670775-A4 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD (CA) | 2009-04-22 | — | — | EP | claimed |
| JP-2007504174-A | — | — | 2007-03-01 | — | — | JP | claimed |
| EP-1670775-A1 | PIPERAZINE SUBTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-06-21 | — | — | EP | claimed |
| WO-2005021523-A1 | PIPERAZINE SUBSTITUTED COMPOUNDS USED AS CALCIUM CHANNEL BLOCKERS | NEUROMED TECHNOLOGIES, INC. (CA) | 2005-03-10 | — | — | WO | claimed |