Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860844 | 0.84 | CHRM4 (0.43) | DRD3CHRM3CHRM4CHRM5KDM4E | |
| SCHEMBL3862213 | 0.82 | KMT2A (0.52) | KCNH2CHRM3HTR1A | |
| SCHEMBL3862105 | 0.79 | HTR7 (0.43) | LMNAALDH1A1PKM | |
| SCHEMBL3869725 | 0.75 | KDM4E (0.40) | CHRM3CHRM4CHRM5KDM4ECHRM2 | |
| SCHEMBL16227060 | 0.75 | CHRM4 (0.49) | KCNH2DRD3CHRM3CHRM4CHRM5 | |
| SCHEMBL5026280 | 0.73 | HRH3 (0.44) | KCNH2CHRM1ALDH1A1 | |
| Benzamide SCHEMBL10723892 | 0.71 | KCNH2 (0.64) | KCNH2DRD3CHRM3KDM4ELMNA | |
| Benzamide SCHEMBL10720284 | 0.71 | KCNH2 (0.64) | KCNH2DRD3CHRM3KDM4ELMNA | |
| SCHEMBL16980657 | 0.71 | SIGMAR1 (0.72) | KCNH2DRD3KDM4EALDH1A1 | |
| SCHEMBL10723980 | 0.70 | SIGMAR1 (0.70) | KCNH2DRD3CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |