Sugi Predict

Sugi Predict / Compounds / SCHEMBL3863284

SCHEMBL3863284

SCHEMBL3863284

CCC(=O)NCCSC(=O)CC

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.60
▸ KMT2A Q03164 1/20 0.60
▸ RECQL P46063 1/20 0.43
▸ STAT3 P40763 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ FAAH O00519 2/20 0.37
▸ TEAD1 P28347 1/20 0.37
▸ YAP1 P46937 1/20 0.37
▸ TEAD4 Q15561 1/20 0.37
▸ TEAD2 Q15562 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ CASP2 P42575 1/20 0.36
▸ ZDHHC7 Q9NXF8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17164975 0.89 MEN1 (0.58) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL18734974 0.86 MEN1 (0.54) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL17164989 0.83 MEN1 (0.50) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL18735139 0.83 MEN1 (0.50) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL6238764 0.83 KMT2A (0.54) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL18734764 0.80 MEN1 (0.47) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL18735155 0.80 MEN1 (0.47) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL17546684 0.79 MEN1 (0.61) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL18734984 0.79 MEN1 (0.50) MEN1KMT2ARECQLSTAT3HSD17B10
SCHEMBL20220317 0.79 MEN1 (0.50) MEN1KMT2ARECQLSTAT3HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9234218-B2 Process for preparing methacrylic acid or methacrylic esters EVONIK ROEHM GMBH (DE) 2016-01-12 — — US disclosed
US-20100291644-A1 PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS EVONIK ROEHM GMBH (DE) 2010-11-18 — — US disclosed
US-20100068773-A1 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID EVONIK ROEHM GMBH (DE) 2010-03-18 — — US disclosed
US-7595300-B2 7-quinolyl ketolide antibacterial agents KOSAN BIOSCIENCES INCORPORATED (US) 2009-09-29 — — US disclosed
US-20080096828-A1 7-Quinolyl ketolide antibacterial agents KOSAN BIOSCIENCES INCORPORATED 2008-04-24 — — US disclosed
WO-2007070536-A2 7-QUINOLYL KETOLIDE ANTIBACTERIAL AGENTS KOSAN BIOSCIENCES INCORPORATED (US) 2007-06-21 — — WO disclosed
EP-1754700-A2 Synthesis of oligoketides Kosan Biosciences, Inc. (US) 2007-02-21 — — EP disclosed
US-7022825-B2 Polyketides and antibiotics KOSAN BIOSCIENCES, INC. (US) 2006-04-04 — — US disclosed
EP-1471923-A4 AMIDO MACROLIDES KOSAN BIOSCIENCES INC (US) 2006-01-11 — — EP disclosed
US-6939861-B2 Amido macrolides KOSAN BIOSCIENCES, INC. (US) 2005-09-06 — — US disclosed
US-20030199458-A1 Amido macrolides KOSAN BIOSCIENCES, INC. 2003-10-23 — — US disclosed
WO-2003061671-A1 AMIDO MACROLIDES KOSAN BIOSCIENCES, INC. (US) 2003-07-31 — — WO disclosed
US-20030096374-A1 Preparation of ketide ester; obtain benzoxazolone derivative, incubate with polyketide synthase, recover ketide oligomer ASHLEY GARY (US) 2003-05-22 — — US disclosed
US-20030092140-A1 Novel polyketides and antibiotics ASHLEY GARY (US) 2003-05-15 — — US disclosed
US-6492562-B1 INVENTION ALSO RELATES TO NOVEL INTERMEDIATES AND THE RESULTING MODIFIED POLYKETIDES AND ANTIBIOTICS. KOSAN BIOSCIENCES, INC. 2002-12-10 — — US disclosed
US-20020128213-A1 Sixteen-membered macrolide compounds KOSAN BIOSCIENCES, INC. 2002-09-12 — — US disclosed
US-20020111317-A1 Sixteen-membered macrolide compounds KOSAN BIOSCIENCES, INC. 2002-08-15 — — US disclosed
EP-1144375-A2 SYNTHESIS OF OLIGOKETIDES Kosan Biosciences (US) 2001-10-17 — — EP disclosed
WO-2000044717-A9 SYNTHESIS OF OLIGOKETIDES — 2001-08-23 — — WO disclosed
WO-2000044717-A2 SYNTHESIS OF OLIGOKETIDES KOSAN BIOSCIENCES, INC. (US) 2000-08-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020111317-A1 Sixteen-membered macrolide compounds NOP2, NSUN3, MRPS23 MEN1 4727/4885KMT2A 2578/4885RECQL 1107/4885
US-20080096828-A1 7-Quinolyl ketolide antibacterial agents CASP7, CYP51A1, RPS27L MEN1 4653/4885KMT2A 1766/4885RECQL 2708/4885
US-20030199458-A1 Amido macrolides PCSK9, ABCB4, PCSK7 MEN1 2706/4885KMT2A 4559/4885RECQL 1683/4885
US-20020128213-A1 Sixteen-membered macrolide compounds NOP2, NSUN3, MRPS23 MEN1 4727/4885KMT2A 2578/4885RECQL 1107/4885
US-20030096374-A1 Preparation of ketide ester; obtain benzoxazolone derivative, incubate with polyketide synthase, recover ketide oligomer COASY, KARS1, ACOT7 MEN1 4480/4885KMT2A 752/4885RECQL 4146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.