Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | TYMP | P19971 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26911545 | 0.72 | LMNA (0.48) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL3786418 | 0.72 | UPP1 (0.57) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL6372044 | 0.71 | LMNA (0.56) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL26911544 | 0.69 | LMNA (0.47) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL26911561 | 0.68 | LMNA (0.56) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL9652779 | 0.68 | KDM4E (0.51) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL10457377 | 0.68 | KDM4E (0.54) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL5017332 | 0.68 | LMNA (0.49) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL827876 | 0.67 | LMNA (0.58) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL26911565 | 0.67 | KDM4E (0.57) | KDM4ECYP1A2GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180339055-A1 | BONE TARGETED THERAPEUTICS AND METHODS OF MAKING AND USING THE SAME | MBC PHARMA INC (US) | 2018-11-29 | — | — | US | disclosed |
| US-20160095932-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | MBC PHARMA, INC. | 2016-04-07 | — | — | US | disclosed |
| US-9216204-B2 | Bone targeted therapeutics and methods of making and using the same | MBC PHARMA, INC. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140051625-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | MBC PHARMA, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8586781-B2 | Bone targeted therapeutics and methods of making and using the same | MBC PHARMA, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-7598246-B2 | Bisphosphonate conjugates and methods of making and using the same | MBC PHARMA, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20090227544-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | MBC PHARMA, INC. (US) | 2009-09-10 | — | — | US | disclosed |
| US-20050026864-A1 | Bisphosphonate conjugates and methods of making and using the same | MBC PHARMA, INC. | 2005-02-03 | — | — | US | disclosed |
| US-6750340-B2 | A BISPHOSPHONATE COMPOUND CONJUGATED WITH ANTIBIOTIC, NUCLEOSIDE, ANTISENSE NUCLEIC ACID AND OTHER DRUGS CAPABLE OF RELEASING ANTIBIOTIC OR CYTOTOXIC COMPONENT UPON BINDING WITH BONE TISSUE; USEFUL FOR TREATING BONE CANCER AND INFECTION | MBC RESEARCH, INC. | 2004-06-15 | — | — | US | disclosed |
| US-20010041689-A1 | Bisphosphonate conjugates and methods of making and using the same | MBC PHARMA, INC. | 2001-11-15 | — | — | US | disclosed |
| US-6214812-B1 | VITAMIN B6 BISPHOSPHONATE CONJUGATE | MBC RESEARCH, INC. | 2001-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051625-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | SOST, BPGM, BST2 | KDM4E 2424/4885CYP1A2 4763/4885GRIA1 1275/4885 |
| US-20010041689-A1 | Bisphosphonate conjugates and methods of making and using the same | SOST, BPGM, PTH1R | KDM4E 3027/4885CYP1A2 3877/4885GRIA1 1261/4885 |
| US-20050026864-A1 | Bisphosphonate conjugates and methods of making and using the same | BPGM, SOST, ENPP2 | KDM4E 2963/4885CYP1A2 4485/4885GRIA1 1371/4885 |
| US-20090227544-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | SOST, BPGM, BST2 | KDM4E 2424/4885CYP1A2 4763/4885GRIA1 1275/4885 |
| US-20160095932-A1 | Bone Targeted Therapeutics and Methods of Making and Using the Same | SOST, BPGM, BST2 | KDM4E 2424/4885CYP1A2 4763/4885GRIA1 1275/4885 |
| US-20180339055-A1 | BONE TARGETED THERAPEUTICS AND METHODS OF MAKING AND USING THE SAME | SOST, BPGM, BST2 | KDM4E 2424/4885CYP1A2 4763/4885GRIA1 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.