SCHEMBL386461

SCHEMBL386461

Cc1c(F)cc(-c2ccccc2NC(=O)c2cn(C)nc2C(F)(F)F)cc1F

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.51
POLB P06746 1/20 0.51
NTRK1 P04629 5/20 0.48
ATM Q13315 1/20 0.45
WDR5 P61964 2/20 0.44
MAPK1 P28482 1/20 0.42
STING1 Q86WV6 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
BACE1 P56817 3/20 0.42
BACE2 Q9Y5Z0 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL303861 0.93 LMNA (0.52) LMNAPOLBNTRK1ATMWDR5
SCHEMBL29688585 0.93 LMNA (0.52) LMNAPOLBNTRK1ATMWDR5
SCHEMBL374213 0.92 LMNA (0.56) LMNAPOLBNTRK1ATMWDR5
SCHEMBL4791610 0.90 LMNA (0.54) LMNAPOLBNTRK1ATMWDR5
SCHEMBL302383 0.89 LMNA (0.53) LMNAPOLBNTRK1ATMWDR5
SCHEMBL373929 0.89 LMNA (0.53) LMNAPOLBNTRK1ATMWDR5
SCHEMBL4443686 0.87 LMNA (0.53) LMNAPOLBNTRK1ATMWDR5
SCHEMBL1085471 0.87 LMNA (0.57) LMNAPOLBNTRK1ATM
SCHEMBL302840 0.86 LMNA (0.60) LMNAPOLBNTRK1ATMSTING1
SCHEMBL14266795 0.86 LMNA (0.54) LMNAPOLBNTRK1ATMSTING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2378882-A2 SYNERGISTIC FUNGICIDAL MIXTURES BASF SE (DE) 2011-10-26 EP claimed
US-20110177944-A1 Synergistic Fungicidal Mixtures BASF SE (DE) 2011-07-21 US claimed
EP-2306832-A2 SYNERGISTIC FUNGICIDAL MIXTURES BASF SE (DE) 2011-04-13 EP claimed
WO-2010072634-A2 POST-HARVEST TREATMENT METHOD BASF SE (DE) 2010-07-01 WO claimed
WO-2010069763-A2 SYNERGISTIC FUNGICIDAL MIXTURES BASF SE (DE) 2010-06-24 WO claimed
WO-2009147205-A2 SYNERGISTIC FUNGICIDAL MIXTURES BASF SE (DE) 2009-12-10 WO claimed
US-20250312289-A1 METHODS AND COMPOSITIONS COMPRISING TOBACCO MILD GREEN MOSAIC VIRUS (TMGMV) UNIV CALIFORNIA (US) 2025-10-09 US disclosed
EP-2991490-B1 APPLYING A PESTICIDE-COMPRISING DISPERSION OF AN ALIPHATIC POLYURETHANE TO PLANTS BASF SE (DE) 2020-10-14 EP disclosed
EP-3102032-B1 SEED COATING FORMULATIONS AND THEIR USE FOR YIELD INCREASE BASF CORP (US) 2019-04-10 EP disclosed
EP-2192837-B1 FUNGICIDAL MIXTURES OF TRITICONAZOLE AND DIFENOCONAZOLE BASF SE (DE) 2017-05-10 EP disclosed
EP-3102032-A1 Seed coating formulations and their use for yield increase BASF Corporation (US) 2016-12-14 EP disclosed
US-20160345575-A1 Seed Coating Formulations and Their Use for Yield Increase BASF CORPORATION (US) 2016-12-01 US disclosed
EP-2408298-B1 METHOD FOR TREATMENT OF CROP WITH AN ENCAPSULATED PESTICIDE BASF SE (DE) 2016-06-29 EP disclosed
WO-2009124920-A2 EMULSIFIABLE CONCENTRATE BASF SE (DE) 2009-10-15 WO disclosed
WO-2009071449-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO disclosed
WO-2009065834-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2009-05-28 WO disclosed
WO-2009056494-A2 USE OF GLYCEROL, METHOD OF CROP TREATMENT, COMPOSITION FOR TANK MIXING AND A METHOD OF PREPARATION OF A COMPOSITION FOR TANK MIXING BASF SE (DE) 2009-05-07 WO disclosed
WO-2009053250-A1 FUNGICIDAL COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF TO COMBAT DAMAGING FUNGI, AND AGENTS COMPRISING THE SAME BASF SE (DE) 2009-04-30 WO disclosed
WO-2009037162-A2 FUNGICIDAL MIXTURES OF TRITICONAZOLE AND DIFENOCONAZOLE BASF SE (DE) 2009-03-26 WO disclosed
WO-2009019176-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2009-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110177944-A1 Synergistic Fungicidal Mixtures CYP3A5, CYP51A1, CYP3A7 LMNA 4642/4885POLB 3322/4885NTRK1 4813/4885
US-20160345575-A1 Seed Coating Formulations and Their Use for Yield Increase CLTB, STUB1, CBLB LMNA 2176/4885POLB 1613/4885NTRK1 2960/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.