Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 8/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872027 | 0.87 | ADRB2 (0.48) | PIK3R2ADRB2NCF1TDP1L3MBTL1 | |
| SCHEMBL2711291 | 0.85 | ADRB2 (0.65) | PIK3R2ADRB2NCF1MAPTMAPK1 | |
| SCHEMBL3867376 | 0.78 | ADRB2 (0.46) | PIK3R2ADRB2MAPTMAPK1 | |
| SCHEMBL19988928 | 0.76 | PIK3R2 (0.68) | PIK3R2 | |
| SCHEMBL2710931 | 0.76 | NT5E (0.48) | NPSR1L3MBTL1ATMKMT2AMAPT | |
| SCHEMBL19989475 | 0.76 | PIK3R2 (0.67) | PIK3R2 | |
| SCHEMBL3869429 | 0.74 | ALDH1A1 (0.49) | NPSR1ATMKMT2AMAPTMAPK1 | |
| SCHEMBL19989359 | 0.74 | PIK3R2 (0.65) | PIK3R2 | |
| SCHEMBL14136437 | 0.72 | ADRB2 (0.58) | ADRB2NCF1TDP1MAPK1TSHR | |
| SCHEMBL11836535 | 0.71 | NT5E (0.46) | PIK3R2NPSR1ATMKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601355-B2 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601355-B2 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601355-B2 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| WO-2007053189-A2 | COMPOSITIONS AND METHODS FOR ALTERING IMMUNE FUNCTION | NORTHWESTERN UNIVERSITY (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070041981-A1 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY | 2007-02-22 | — | — | US | disclosed |
| US-20070041981-A1 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY | 2007-02-22 | — | — | US | disclosed |
| US-20070041981-A1 | Compositions and methods for altering immune function | NORTHWESTERN UNIVERSITY | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070041981-A1 | Compositions and methods for altering immune function | IL2, ICOS, IFNG | PIK3R2 2774/4885NPSR1 3456/4885ADRB2 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.