Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16252401 | 0.94 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL16252402 | 0.94 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL174531 | 0.87 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL22805526 | 0.82 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL18840973 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KMT2AHTTRAB9ALMNA | |
| SCHEMBL24218363 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL18840958 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2HTTRAB9A | |
| SCHEMBL17714338 | 0.79 | PAX8 (0.54) | ALDH1A1KMT2AMEN1SMN1; SMN2PKM | |
| SCHEMBL18840970 | 0.79 | MAPT (0.48) | ALDH1A1KMT2AHTTRAB9ALMNA | |
| SCHEMBL4075658 | 0.76 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201013-B1 | NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-D] PYRIMIDINE AND PYRROLO [2,3-D] PYRIMIDINE AND USES THEREOF | UNIV SIENA (IT) | 2014-11-19 | — | — | EP | disclosed |
| US-7589086-B2 | Substituted pyrazolo[3,4-D]pyrimidines as anti-tumor agents | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-15 | — | — | US | disclosed |
| EP-1638966-B1 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO ¬3,4-d PYRIMIDINE AND USES THEREOF | UNIV SIENA (IT) | 2008-03-19 | — | — | EP | disclosed |
| US-20070010510-A1 | 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010510-A1 | 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof | DPYD, TYMP, TYMS | ALDH1A1 1297/4885KMT2A 3147/4885MEN1 3827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.