Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | SCN4A | P35499 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198692 | 0.98 | ADRB2 (0.52) | ADRB2SLC2A1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL23222166 | 0.87 | SLC2A1 (0.48) | ADRB2SLC2A1SLC6A4AOC3KDM4E | |
| SCHEMBL4985324 | 0.86 | SLC2A1 (0.51) | ADRB2SLC2A1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8438898 | 0.84 | SLC2A1 (0.58) | ADRB2SLC2A1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL19559157 | 0.83 | SLC2A1 (0.43) | ADRB2SLC2A1SLC6A4IDO1RAB9A | |
| SCHEMBL16649759 | 0.80 | SLC6A4 (0.50) | ADRB2SLC6A3SLC6A2SLC6A4SCN4A | |
| SCHEMBL12262253 | 0.80 | SLC6A4 (0.57) | ADRB2SLC6A3SLC6A2SLC6A4SCN4A | |
| SCHEMBL1977034 | 0.80 | SLC6A4 (0.57) | ADRB2SLC6A3SLC6A2SLC6A4SCN4A | |
| SCHEMBL390989 | 0.80 | SLC6A4 (0.57) | ADRB2SLC6A3SLC6A2SLC6A4SCN4A | |
| SCHEMBL1534396 | 0.80 | SLC6A4 (0.50) | ADRB2SLC6A3SLC6A2SLC6A4SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190679-A1 | Novel Protein Kinase B Inhibitors - 060 | ASTRAZENECA AB (SE) | 2012-07-26 | — | — | US | disclosed |
| US-8101623-B2 | Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor | ASTRAZENECA AB (SE) | 2012-01-24 | — | — | US | disclosed |
| US-20090163524-A1 | Novel Protein Kinase B Inhibitors - 060 | ASTRAZENECA AB (SE) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163524-A1 | Novel Protein Kinase B Inhibitors - 060 | PRKAR2B, PRKCB, MAP3K20 | ADRB2 1387/4885SLC2A1 2482/4885SLC6A3 4759/4885 |
| US-20120190679-A1 | Novel Protein Kinase B Inhibitors - 060 | PRKAR2B, PRKCB, MAP3K20 | ADRB2 1387/4885SLC2A1 2482/4885SLC6A3 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.