Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860266 | 0.92 | MTNR1A (0.45) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3860080 | 0.84 | IDO1 (0.51) | MTNR1AMTNR1BNPC1RAB9APOLB | |
| SCHEMBL17960754 | 0.83 | SMN1; SMN2 (0.54) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL17960683 | 0.82 | MTNR1A (0.50) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3859644 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3446802 | 0.79 | MTNR1A (0.73) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL612876 | 0.77 | HAO1 (0.46) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL25380954 | 0.77 | DRD2 (0.60) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3858312 | 0.77 | TAAR1 (0.56) | HPGDSMN1; SMN2MAOB | |
| SCHEMBL3870188 | 0.76 | L3MBTL1 (0.50) | MTNR1AMTNR1BHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |