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SCHEMBL3869811

SCHEMBL3869811

Cc1ccc([Si](Oc2ccccc2)(Oc2ccccc2)c2ccc(C)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.42
▸ ACHE P22303 3/20 0.42
▸ TSHR P16473 2/20 0.42
▸ ALOX12 P18054 1/20 0.42
▸ HTT P42858 3/20 0.40
▸ SMN1; SMN2 Q16637 3/20 0.40
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ DRD2 P14416 2/20 0.38
▸ DRD4 P21917 2/20 0.38
▸ DRD3 P35462 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ CA4 P22748 1/20 0.37
▸ HPGD P15428 2/20 0.37
▸ TDP1 Q9NUW8 3/20 0.35
▸ POLB P06746 2/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ NFKB1 P19838 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3875429 0.91 LMNA (0.42) LMNAACHETSHRALOX12HTT
SCHEMBL3867442 0.89 ACHE (0.46) LMNAACHETSHRHTTSMN1; SMN2
SCHEMBL704591 0.86 LTA4H (0.41) TSHRMEN1KMT2AALDH1A1MAPT
SCHEMBL431218 0.84 LTA4H (0.43) TSHRMEN1KMT2AALDH1A1MAPT
SCHEMBL3878886 0.83 ACHE (0.42) LMNAACHETSHRALOX12HTT
SCHEMBL3869832 0.83 ACHE (0.42) LMNAACHETSHRALOX12HTT
SCHEMBL13968168 0.80 SMN1; SMN2 (0.44) LMNATSHRHTTSMN1; SMN2MEN1
SCHEMBL10323853 0.77 HTT (0.47) LMNAACHETSHRALOX12HTT
SCHEMBL10323805 0.77 HTT (0.47) LMNAACHETSHRALOX12HTT
SCHEMBL3481943 0.76 ACHE (0.43) LMNAACHETSHRALOX12HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7129311-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-10-31 — — US claimed
US-20060159861-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-07-20 — — US claimed
EP-1573086-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES Arch Specialty Chemicals, Inc. (US) 2005-09-14 — — EP claimed
US-20040127070-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. 2004-07-01 — — US claimed
WO-2004027110-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES ARCH SPECIALTY CHEMICALS, INC. (US) 2004-04-01 — — WO claimed
US-7531590-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2009-05-12 — — US disclosed
US-20060270787-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes VERSUM MATERIALS US, LLC 2006-11-30 — — US disclosed
US-7129311-B2 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-10-31 — — US disclosed
US-20060159861-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. (US) 2006-07-20 — — US disclosed
EP-1573086-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES Arch Specialty Chemicals, Inc. (US) 2005-09-14 — — EP disclosed
US-20040127070-A1 Additives to prevent degradation of alkyl-hydrogen siloxanes ARCH SPECIALTY CHEMICALS, INC. 2004-07-01 — — US disclosed
WO-2004027110-A2 ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES ARCH SPECIALTY CHEMICALS, INC. (US) 2004-04-01 — — WO disclosed