Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | F11 | P03951 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861228 | 0.85 | CFD (0.45) | CFDTPSB2TAAR1KMT2ASMN1; SMN2 | |
| SCHEMBL3863909 | 0.83 | CFD (0.37) | CFDTPSB2 | |
| SCHEMBL3865749 | 0.83 | CFD (0.37) | CFDTPSB2TAAR1KMT2ANOS1 | |
| SCHEMBL3870016 | 0.76 | CFD (0.35) | CFDTPSB2 | |
| SCHEMBL3859911 | 0.75 | CFD (0.34) | CFDTPSB2 | |
| SCHEMBL3706015 | 0.73 | SLC7A5 (0.56) | CFDTPSB2KMT2ASMN1; SMN2F11 | |
| SCHEMBL3706013 | 0.73 | SLC7A5 (0.56) | CFDTPSB2KMT2ASMN1; SMN2F11 | |
| SCHEMBL3865711 | 0.73 | CFD (0.45) | CFDTPSB2TAAR1KMT2ASMN1; SMN2 | |
| SCHEMBL24527630 | 0.71 | AOC3 (0.53) | TAAR1 | |
| SCHEMBL382558 | 0.71 | AOC3 (0.53) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |