Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861228 | 0.89 | CFD (0.45) | CFDTPSB2KCNH2TAAR1KMT2A | |
| SCHEMBL3870084 | 0.83 | CFD (0.39) | CFDTPSB2NOS1NOS2TAAR1 | |
| SCHEMBL24527613 | 0.77 | AOC3 (0.42) | CFDTPSB2TACR1TAAR1 | |
| SCHEMBL3870016 | 0.77 | CFD (0.35) | CFDTPSB2RAB9A | |
| SCHEMBL3865711 | 0.77 | CFD (0.45) | CFDTPSB2TAAR1KMT2A | |
| SCHEMBL3859911 | 0.76 | CFD (0.34) | CFDTPSB2RAB9A | |
| SCHEMBL3386789 | 0.72 | ALOX5 (0.40) | — | |
| SCHEMBL14782317 | 0.72 | ALOX5 (0.40) | — | |
| SCHEMBL3950229 | 0.70 | MTNR1A (0.44) | MEN1KMT2A | |
| SCHEMBL15902671 | 0.69 | FFAR1 (0.41) | KCNH2TAAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |