Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Liothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 14/20 | 0.97 |
| ▸ | THRA known ✓ | P10827 | 10/20 | 0.97 |
| ▸ | LMNA | P02545 | 6/20 | 0.97 |
| ▸ | MEN1 | O00255 | 6/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.97 |
| ▸ | PCNA | P12004 | 4/20 | 0.97 |
| ▸ | PPARG | P37231 | 4/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.97 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.97 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.97 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | GABRP | O00591 | 1/20 | 0.97 |
| ▸ | GABRD | O14764 | 1/20 | 0.97 |
| ▸ | F2 | P00734 | 1/20 | 0.97 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.97 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.97 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.97 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL21749451 | 1.00 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL29651848 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL3287278 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL8301 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Rathyronine SCHEMBL123365 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL29383803 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL8300 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL29390909 | 0.99 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL4608153 | 0.97 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL2679283 | 0.97 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 401 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122038285-A | Kit and method for constructing human bone organ by using pluripotent stem cells | 广东医科大学附属医院 | 2026-05-15 | — | — | CN | claimed |
| CN-118480508-A | Culture medium capable of increasing expression of CD11b by THP-1 cells | 上海源培生物科技股份有限公司 | 2024-08-13 | — | — | CN | claimed |
| WO-2024123237-A1 | USE OF CONDITIONED MEDIUM OF CORD LINING MESENCHYMAL STEM CELLS FOR HEALING AND/OR PREVENTING THE FORMATION AND/OR RECURRENCE OF A WOUND OR A DAMAGED SKIN AREA | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2024-06-13 | — | — | WO | claimed |
| WO-2024107122-A1 | USE OF CONDITIONED MEDIUM DERIVED FROM CULTIVATION OF MESENCHYMAL STEM CELLS OF THE UMBILICAL CORD FOR INDUCING, STIMULATING AND PROMOTING HAIR GROWTH AND REGENERATION | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2024-05-23 | — | — | WO | claimed |
| WO-2024107102-A1 | USE OF CONDITIONED MEDIUM DERIVED FROM CULTIVATION OF MESENCHYMAL STEM CELLS OF THE UMBILICAL CORD FOR INDUCING, STIMULATING AND PROMOTING HAIR GROWTH AND REGENERATION | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2024-05-23 | — | — | WO | claimed |
| US-11987813-B2 | Microenvironments for self-assembly of islet organoids from stem cells differentiation | The Research Foundation for The Sate University of New York (US) | 2024-05-21 | — | — | US | claimed |
| US-20240141298-A1 | METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD, A MESENCHYMAL STEM CELL POPULATION ISOLATED FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD AND A CELL CULTURE MEDIUM FOR ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2024-05-02 | — | — | US | claimed |
| US-11821006-B2 | Method of isolating mesenchymal stem cells from the amniotic membrane of the umbilical cord, a mesenchymal stem cell population isolated from the amniotic membrane of the umbilical cord and a cell culture medium for isolating mesenchymal stem cells from the amniotic membrane of the umbilical cord | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2023-11-21 | — | — | US | claimed |
| CN-116829721-A | Method for producing induced pluripotent stem cells, and method for using the induced pluripotent stem cells | 细胞研究私人有限公司 | 2023-09-29 | — | — | CN | claimed |
| US-20230285470-A1 | A METHOD OF GENERATING AN INDUCED PLURIPOTENT STEM CELL, AN INDUCED PLURIPOTENT STEM CELL AND METHODS OF USING THE INDUCED PLURIPOTENT STEM CELL | CELLRESEARCH CORPORATION PTE LTD (SG) | 2023-09-14 | — | — | US | claimed |
| US-20180127721-A1 | METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD, A MESENCHYMAL STEM CELL POPULATION ISOLATED FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD AND A CELL CULTURE MEDIUM FOR ISOLATING MESENCHYMAL STEM CELLS FROM THE AMNIOTIC MEMBRANE OF THE UMBILICAL CORD | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2018-05-10 | — | — | US | claimed |
| WO-2018067071-A1 | A METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM UMBILICAL CORD AMNIOTIC MEMBRANE USING A CELL CULTURE MEDIUM | CELLRESEARCH CORPORATION PTE. LTD. (SG) | 2018-04-12 | — | — | WO | claimed |
| WO-2016166418-A2 | IN VITRO MODEL OF CHRONIC INFLAMMATION | TAMPEREEN YLIOPISTO (FI) | 2016-10-20 | — | — | WO | claimed |
| WO-2016160717-A1 | ENDOCHONDRAL TISSUE ENGINEERING FOR VASCULARIZED BONE REGENERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-06 | — | — | WO | claimed |
| CN-102858156-A | Methods, compositions and kits for providing therapy | ASHUR-FABIAN OSNAT | 2013-01-02 | — | — | CN | claimed |
| CN-102625689-A | Method and composition for restoration of age-related tissue loss in the face or selected areas of the body | NEOSTEM INC | 2012-08-01 | — | — | CN | claimed |
| US-7858663-B1 | Physical and chemical properties of thyroid hormone organic acid addition salts | PISGAH LABORATORIES, INC. (US) | 2010-12-28 | — | — | US | claimed |
| CN-1156591-A | Oxytocic aid for fishes and hasten parturition method thereof | QIAN JIADA (CN) | 1997-08-13 | — | — | CN | claimed |
| CN-1127634-A | Controlled release hormone microsphere injection and preparing method thereof | CHENGDU ORGANIC CHEM INST (CN) | 1996-07-31 | — | — | CN | claimed |
| CN-1126589-A | Injecta of delayed hormone microcapsule and its prepn | CHENGDU ORGANIC CHEM INST (CN) | 1996-07-17 | — | — | CN | claimed |