Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.45 |
| ▸ | FEN1 | P39748 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412917 | 0.90 | MEN1 (0.54) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL3877890 | 0.83 | ALOX5AP (0.45) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL3880121 | 0.82 | MEN1 (0.48) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL3886420 | 0.79 | HPGDS (0.52) | MEN1KMT2AALOX5APFEN1HSD11B1 | |
| SCHEMBL3885085 | 0.79 | ALOX5AP (0.49) | MEN1KMT2AALDH1A1ALOX5APFEN1 | |
| SCHEMBL3873142 | 0.79 | ALOX5AP (0.45) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL3881888 | 0.77 | HSD11B1 (0.61) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL3874676 | 0.76 | UBE2M (0.45) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL409440 | 0.75 | MEN1 (0.50) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL2227173 | 0.74 | GRM5 (0.50) | MEN1KMT2ATSHRHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-A1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX Pharma S.A. (CH) | 2009-03-04 | — | — | EP | claimed |
| EP-1685105-B1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2008-10-15 | — | — | EP | claimed |