Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.66 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873213 | 0.88 | CYP19A1 (0.70) | CYP19A1NAMPTADAMTS4MMP13KAT6A | |
| SCHEMBL3874748 | 0.88 | NAMPT (0.60) | CYP19A1NAMPTADAMTS4MMP13KCNA5 | |
| SCHEMBL3877412 | 0.84 | CYP19A1 (0.62) | CYP19A1NAMPTKCNA5KAT6APOLB | |
| SCHEMBL3872490 | 0.82 | CYP19A1 (0.68) | CYP19A1NAMPTKCNA5POLBLOXL2 | |
| SCHEMBL14049769 | 0.80 | NAMPT (0.52) | CYP19A1NAMPTKCNA5POLBLOXL2 | |
| SCHEMBL3874284 | 0.80 | CYP19A1 (0.58) | CYP19A1NAMPTMMP13KAT6APOLB | |
| SCHEMBL3883802 | 0.79 | CYP19A1 (0.57) | CYP19A1KAT6ALMNAHPGD | |
| SCHEMBL3874725 | 0.78 | ALDH1A1 (0.59) | CYP19A1KAT6APOLBCA2OPRK1 | |
| SCHEMBL1169813 | 0.78 | CYP19A1 (0.60) | CYP19A1NAMPTKCNA5POLBOPRK1 | |
| SCHEMBL3871576 | 0.77 | POLB (0.78) | CYP19A1NAMPTKCNA5KAT6APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20090069323-A1 | 11beta-hsdi inhibitors | EVOTEC AG (DE) | 2009-03-12 | — | — | US | disclosed |
| EP-1814846-A1 | 11BETA-HSD1 INHIBITORS | Evotec AG (DE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006048330-A1 | 11ΒΕΤΑ-HSD1 INHIBITORS | EVOTEC AG (DE) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069323-A1 | 11beta-hsdi inhibitors | HSD3B1, HSD3B2, HSD11B1 | CYP19A1 23/4885NAMPT 2223/4885ADAMTS4 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.