Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HK1 | P19367 | 1/20 | 0.46 |
| ▸ | HK2 | P52789 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872680 | 0.89 | ALDH1A1 (0.64) | ALDH1A1PKMKMT2AMEN1POLB | |
| SCHEMBL3883802 | 0.88 | CYP19A1 (0.57) | ALDH1A1CYP19A1KMT2AROCK2PKN2 | |
| SCHEMBL3874284 | 0.81 | CYP19A1 (0.58) | CYP19A1POLBKAT6AOPRK1HTT | |
| SCHEMBL3873213 | 0.81 | CYP19A1 (0.70) | CYP19A1POLBKAT6ACA2HK1 | |
| SCHEMBL3879290 | 0.81 | ALDH1A1 (0.66) | ALDH1A1PKMCYP19A1KMT2AMEN1 | |
| SCHEMBL3875005 | 0.78 | CYP19A1 (0.66) | CYP19A1POLBKAT6ACA2OPRK1 | |
| SCHEMBL3875950 | 0.77 | TSHR (0.61) | ALDH1A1KMT2AHDAC6OPRK1SMN1; SMN2 | |
| SCHEMBL3877412 | 0.76 | CYP19A1 (0.62) | ALDH1A1CYP19A1POLBKAT6AOPRK1 | |
| SCHEMBL3875842 | 0.74 | HTT (0.75) | ALDH1A1POLBHDAC6CA2OPRK1 | |
| SCHEMBL3872261 | 0.74 | ALDH1A1 (0.56) | ALDH1A1PKMKMT2AMEN1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20090069323-A1 | 11beta-hsdi inhibitors | EVOTEC AG (DE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069323-A1 | 11beta-hsdi inhibitors | HSD3B1, HSD3B2, HSD11B1 | ALDH1A1 210/4885PKM 1568/4885CYP19A1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.