Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9695815 | 1.00 | MLYCD (0.67) | MLYCDHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL5697460 | 0.93 | NPC1 (0.61) | MLYCDHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL9337665 | 0.88 | MLYCD (0.76) | MLYCDNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6263516 | 0.88 | MLYCD (0.76) | MLYCDNPC1RAB9AMEN1KMT2A | |
| SCHEMBL22103804 | 0.87 | MAPT (0.63) | MLYCDTRPV1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7303163 | 0.87 | HDAC3 (0.86) | HDAC3HDAC11HDAC8HDAC6TRPV1 | |
| SCHEMBL7514354 | 0.84 | MLYCD (0.76) | MLYCDHDAC3HDAC8HDAC6TRPV1 | |
| SCHEMBL1638233 | 0.84 | NPC1 (0.73) | MLYCDNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL11059466 | 0.84 | NPC1 (0.73) | MLYCDNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9695767 | 0.83 | HDAC3 (0.65) | HDAC3HDAC11HDAC8HDAC6TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-7595332-B2 | Amides that inhibit vanilloid receptor subtype 1 (VR1) | ABBOTT LABORATORIES (US) | 2009-09-29 | — | — | US | disclosed |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | SHIONOGI & CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| EP-1959944-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | Shionogi Co., Ltd. (JP) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007069773-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007069773-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING AN AMIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-06-21 | — | — | WO | disclosed |
| US-20060122231-A1 | Amides that inhibit vanilloid receptor subtype 1 (VR1) | ABBVIE INC. | 2006-06-08 | — | — | US | disclosed |
| US-7037927-B2 | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor | ABBOTT LABORATORIES (US) | 2006-05-02 | — | — | US | disclosed |
| US-20050085512-A1 | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor | ABBVIE INC. | 2005-04-21 | — | — | US | disclosed |
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122231-A1 | Amides that inhibit vanilloid receptor subtype 1 (VR1) | TRPV1, OPRL1, AVPR2 | MLYCD 4451/4885HDAC3 1833/4885HDAC11 935/4885 |
| US-20090163549-A1 | Pharmaceutical Composition Comprising an Amide Derivative | TRPV1, TRPA1, TRPV2 | MLYCD 3945/4885HDAC3 344/4885HDAC11 665/4885 |
| US-20050085512-A1 | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor | TRPV1, OPRL1, AVPR1A | MLYCD 4260/4885HDAC3 1725/4885HDAC11 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.