Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 3/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364010 | 0.75 | ALDH1A1 (0.36) | MAPTCDK2KDM4EALDH1A1 | |
| SCHEMBL9368918 | 0.75 | ALDH1A1 (0.47) | GAAMAPTPKMALDH1A1HPGD | |
| SCHEMBL9668607 | 0.74 | KDM4E (0.35) | GAAMAPTPKMTSHRKDM4E | |
| SCHEMBL1951450 | 0.71 | ALDH1A1 (0.42) | GAACDK2PKMTSHRKDM4E | |
| SCHEMBL3452770 | 0.71 | ALDH1A1 (0.54) | GAAMAPTCDK2KDM4EALDH1A1 | |
| SCHEMBL9363575 | 0.68 | PKM (0.51) | GAAPKMTSHRALDH1A1 | |
| SCHEMBL11551662 | 0.65 | PKM (0.59) | GAAPKMTSHRALDH1A1 | |
| SCHEMBL9367365 | 0.65 | PKM (0.59) | GAAPKMTSHRALDH1A1HPGD | |
| SCHEMBL9367320 | 0.65 | ALDH1A1 (0.35) | PDE4BGAACDK2ALDH1A1PDE4A | |
| SCHEMBL20552051 | 0.64 | PKM (0.42) | GAACDK2PKMTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094670-A1 | HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY | AstraZeneca AB (SE) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008056150-A1 | HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | WO | disclosed |