Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878435 | 1.00 | MRGPRX4 (0.39) | MRGPRX4DHODHDCLRE1BPOLBALDH1A1 | |
| SCHEMBL3878437 | 0.81 | DHODH (0.38) | MRGPRX4DHODHPOLBALDH1A1TP53 | |
| SCHEMBL4514869 | 0.81 | RAB9A (0.40) | POLBALDH1A1CNR1 | |
| SCHEMBL4513890 | 0.65 | DHODH (0.38) | DHODHMARS1SRD5A2 | |
| SCHEMBL4505429 | 0.65 | DHODH (0.50) | DHODHALDH1A1TP53SRD5A2CNR1 | |
| SCHEMBL442223 | 0.64 | ALDH1A1 (0.58) | MRGPRX4ALDH1A1TP53SRD5A2CA1 | |
| SCHEMBL16950095 | 0.62 | TSHR (0.72) | ALDH1A1CA1CA2CA9 | |
| SCHEMBL5455142 | 0.61 | ALDH1A1 (0.61) | MRGPRX4ALDH1A1TP53 | |
| SCHEMBL27853748 | 0.61 | ALDH1A1 (0.61) | MRGPRX4ALDH1A1TP53SRD5A2CA1 | |
| SCHEMBL69352 | 0.61 | TSHR (0.68) | POLBALDH1A1TP53CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010492-A2 | AMINOMETHYL PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007119001-A2 | AMINOMETHYL PYRIDINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-10-25 | — | — | WO | disclosed |