Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12980 | 0.85 | ADRB1 (0.62) | MAPTTP53POLBADRB1SLC6A9 | |
| SCHEMBL3876194 | 0.85 | MAPT (0.49) | MAPTTP53POLBADRB1SLC6A9 | |
| SCHEMBL6740206 | 0.78 | LMNA (0.70) | MAPTPOLBALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL6739807 | 0.78 | AKR1C3 (0.63) | MAPTTP53ADRB1SLC6A9SLC6A5 | |
| SCHEMBL9619196 | 0.78 | KDM4E (0.58) | ALDH1A1MAPK1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10373770 | 0.76 | ADRB1 (0.74) | MAPTADRB1ALDH1A1L3MBTL1KCNH2 | |
| SCHEMBL11103700 | 0.76 | ADRB1 (0.74) | MAPTADRB1ALDH1A1L3MBTL1KCNH2 | |
| SCHEMBL12644442 | 0.75 | MAPT (0.58) | MAPTALDH1A1MAPK1CYP1A2CYP3A4 | |
| SCHEMBL11096302 | 0.75 | KCNH2 (0.73) | MAPTADRB1ALDH1A1KCNH2CYP2C19 | |
| SCHEMBL12110268 | 0.75 | KMT2A (0.56) | MAPTALDH1A1MAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |