Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831221 | 0.84 | KDM4E (0.45) | NR1H2NR1H3HSD17B1HSD17B2CRBN | |
| SCHEMBL5277970 | 0.84 | ITGB1 (0.40) | ITGB1ITGA5CRBNKMT2ACES2 | |
| SCHEMBL2083044 | 0.83 | DRD2 (0.34) | ITGB1ITGA5TUBB1MEN1KMT2A | |
| SCHEMBL2611545 | 0.82 | HTT (0.40) | NR1H2NR1H3HSD17B1HSD17B2CRBN | |
| SCHEMBL30645198 | 0.82 | HTT (0.40) | NR1H2NR1H3HSD17B1HSD17B2CRBN | |
| SCHEMBL6170434 | 0.80 | ALDH1A1 (0.39) | NR1H2NR1H3HSD17B1HSD17B2CRBN | |
| SCHEMBL5255903 | 0.80 | CES2 (0.44) | ITGB1ITGA5TUBB1POLBCES2 | |
| SCHEMBL2829961 | 0.80 | KMT2A (0.42) | NR1H2NR1H3KMT2AUSP2TSHR | |
| SCHEMBL6580698 | 0.79 | ITGB1 (0.38) | ITGB1ITGA5HSD17B1HSD17B2CES2 | |
| SCHEMBL607945 | 0.79 | HSD17B10 (0.44) | NR1H2NR1H3HSD17B1HSD17B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-B1 | AMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN SEIYAKU KK (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-2383271-B1 | Aminoquinolones as GSK-3 Inhibitors | KYORIN SEIYAKU KK (JP) | 2013-07-10 | — | — | EP | disclosed |
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |